VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to: 1) treat and control bleeding episodes; 2) prevent excessive bleeding during and after surgery

Detailed Important Risk Information Patient Information Visit provider site

Living with von willebrand disease (vwd)

A rare disease with unique impacts

Bleeding caused by VWD can affect every part of your life, from your career to your hobbies to your family life. However, everyone's experience is different.¹

Real VWD patient Leslie holding her backpack straps and smiling.

With VWD, bleeds are always a risk

People living with VWD experience different types of bleeds that affect them in different ways. In a CDC study of 102 women with VWD, 95% report heavy menstrual bleeding, while 92% report bleeding after minor injuries.²

Real VWD patient Nicole walking on a sidewalk holding her purse.

Real VWD
patients. Real experiences.

Cuts & bruises Menstrual bleeds Nosebleeds

Leslie's story

Diagnosed with VWD in 2003

"When I fell, I would be covered with big, painful bruises, and the cuts I got would bleed a lot."

See Leslie's story

Nicole's story

Diagnosed with VWD in 2009

"In junior high school and high school, I began to miss days every time I had my menstrual cycle."

See Nicole's story

Erica's story

Diagnosed with VWD in 1981

"Over the years, I tried all kinds of different medications. I saw loads of hematologists. They always assumed sickle cell or hemophilia. It was very frustrating."

See Erica's story

Real VWD patient Erica with her hand in her pocket smiling at the camera.

How VWD can affect women

Even though VWD occurs with similar frequency in both men and women, it's sometimes viewed as affecting women more often. This is likely because women face the challenge of increased or prolonged bleeding during menstrual periods (menorrhagia or heavy menstrual bleeding) and childbirth.³

Some signs of heavy menstrual bleeding include⁴:

Bleeding for more than 7 days
Changing a tampon or pad every 2 hours or less
Passing blood clots larger than 1 quarter

To remember these signs of heavy menstrual bleeding, just think 7, 2, 1.

Ready to talk to your healthcare provider?

Our easy-to-use Discussion Guide, used alongside our bleed tracker, can help you speak to your healthcare provider about finding a treatment that's right for you.

Download the guide

von Willebrand disease discussion guide.

Real VWD patient Erica sitting around the table with her family and friends.

Is VONVENDI^® [von Willebrand factor (Recombinant)] right for you?

VONVENDI was created specifically to treat bleeding episodes in adults with VWD. When infused into your blood stream, it acts like your body's natural von Willebrand factor (VWF), helping to form clots, and helping your own FVIII to work.⁵¹¹¹

VONVENDI is approved for use in adults with VWD Types 1, 2, and 3.⁶¹² It can also be prescribed to manage bleeds in three different ways:

Prophylactically as part of a regular routine for adults with severe type 3 VWD¹¹¹⁵
On-demand during active bleeds¹¹¹⁵
Perioperatively to prevent excessive bleeding during and after surgery¹¹¹⁵

Discover VONVENDI

Woman wearing a sweater looking at VONVENDI® information on her tablet.

More facts about VWD

Get to know the most common inherited bleeding disorder.⁷⁴¹

Learn more

Doctor going over VONVENDI® documents with her patient.

VONVENDI safety

See the most common side effects.

Learn more

See Detailed Important Risk Information

What is VONVENDI?

VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to:

treat and control bleeding episodes
prevent excessive bleeding during and after surgery
reduce the number of bleeding episodes when used regularly (prophylaxis) in adults with severe Type 3 von Willebrand disease receiving on-demand therapy

Who should not use VONVENDI?

You should not use VONVENDI if you:

Are allergic to any ingredients in VONVENDI
Are allergic to mice or hamsters

VONVENDI^® [von Willebrand factor (Recombinant)] Important Information

What is VONVENDI?

VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to:

treat and control bleeding episodes
prevent excessive bleeding during and after surgery
reduce the number of bleeding episodes when used regularly (prophylaxis) in adults with severe Type 3 von Willebrand disease receiving on-demand therapy

Detailed Important Risk Information

Who should not use VONVENDI?

You should not use VONVENDI if you:

Are allergic to any ingredients in VONVENDI.
Are allergic to mice or hamsters.

Tell your healthcare provider if you are pregnant or breastfeeding because VONVENDI may not be right for you.

How should I use VONVENDI?

Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.

Your healthcare provider will instruct you whether additional doses of VONVENDI with or without recombinant factor VIII are needed.

What should I tell my healthcare provider before I use VONVENDI?

You should tell your healthcare provider if you:

Have or have had any medical problems.
Take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
Have any allergies, including allergies to mice or hamsters.
Are breastfeeding. It is not known if VONVENDI passes into your milk and if it can harm your baby.
Are pregnant or planning to become pregnant. It is not known if VONVENDI can harm your unborn baby.
Have been told that you have inhibitors to von Willebrand factor (because VONVENDI may not work for you).
Have been told that you have inhibitors to blood coagulation factor VIII.

What else should I know about VONVENDI and von Willebrand Disease?

Your body can form inhibitors to von Willebrand factor or factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, it may stop VONVENDI or factor VIII from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.

What are the possible side effects of VONVENDI?

You can have an allergic reaction to VONVENDI.

Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.

Side effects that have been reported with VONVENDI include: headache, nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, joint pain, joint injury, increased liver enzyme level in blood, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots and increased heart rate.

Tell your healthcare provider about any side effects that bother you or do not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see VONVENDI full Prescribing Information

References

10 things every adult should know. National Hemophilia Foundation, Steps for Living. Accessed July 9, 2020. https://stepsforliving.hemophilia.org/step-out/10-things-every-adult-should-know
Data and Statistics on von Willebrand Disease. CDC website. Accessed July 9, 2020. https://www.cdc.gov/ncbddd/vwd/data.html
Von Willebrand disease. National Organization for Rare Disorders website. Accessed July 9, 2020. https://rarediseases.org/rare-diseases/von-willebrand-disease/
Effects of puberty on girls with a bleeding disorder. Steps for Living website. Accessed July 9, 2020. https://stepsforliving.hemophilia.org/next-step/maintaining-a-healthy-body/growing-up-puberty/effects-of-puberty-on-girls-with-a-bleeding-disorder
VONVENDI Prescribing Information
Baxalta receives FDA Approval for VONVENDI, the first and only recombinant treatment for adults affected by von Willebrand disease. Business Wire. December 8, 2015. Accessed July 9, 2020. https://www.businesswire.com/news/home/20151208006689/en/Baxalta-Receives-FDA-Approval-VONVENDIRecombinant-Treatment
What is von Willebrand disease? Centers for Disease Control and Prevention website. Accessed July 9, 2020. http://www.cdc.gov/ncbddd/vwd/facts.html